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KMID : 0380620110430020189
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Korean Journal of Food Science and Technology
2011 Volume.43 No. 2 p.189 ~ p.194
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Anti-obesity Effect of Sargassum confusum Ethanol Extract in Obese Rats
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Jang Yu-Jung
Kwon Sang-Oh
Yeo Kyung-Mok
Hong Mi-Jung
Kim Bok-Nam
Han Dae-Seok
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Abstract
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Effect of Sargassum confusum extract on the reduction of body weight gain and lipid contents in obese rats were evaluated to find natural materials with anti-obesity benefits. After inducing obesity by feeding 42.5% high-fat diet for 5 weeks, each 10 Sprague-Dawley rats were randomly assigned to high-fat diet control (HFD) group and high-fat diet group containing 3% Sargassum confusum extract (HFDSC). Weight gain of HFD group (2.96±0.31 g/day) was significantly (p<0.05) higher as compared to that of normal diet (ND) group (2.19±0.17 g/day). Weights of adipose tissues of HFD group were higher than those of ND group. Body weight gain of HFDSC group, however, was 2.36±0.24 g/day, which was significantly (p<0.05) lower by 21% than that of HFD group. In addition, weights of epididymal and perirenal adipose tissues were lower by 15% and 16%, respectively, as compared to those of HFD group. Biochemical analyses showed that concentration of triglyceride, total cholesterol, and fatty acids were significantly (p<0.05) lower in HFDSC group. These results suggest that Sargassum confusum extract has a high potential as an anti-obesity material by reducing weight gain and obesity-related factors in serum.
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KEYWORD
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Sargassum confusum, anti-obesity, high-fat diet, weight gain, adipose tissue
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